关键词: 近视；信号转导  ,

Abstract: With the increasing prevalence of myopia in China, many studies have been done to explore the pathogenesis of myopia to prevent and treat myopia effectively. Previous studies have shown that the abnormal visual stimulation of myopia is detected by retinal neurons, which generates signals through RPE and choroid into sclera, resulting in scleral remodeling and axial elongation. However, it is not clear how signals are transducted from retina to sclera. Studies have found that TGF-β/Smad, JAK/STAT, retinoic acid, PPAR, Wnt/β-catenin, dopamine, acetylcholine receptor and GABA signaling pathways play an important role in transduction, the study of which has significant clinical value in the prevention and treatment of myopia. (Int Rev Ophthalmol, 2020, 44：  318-323)

Key words: myopia, signal transduction