Abstract:

All-trans retinoid acid (ATRA) is one of the vital metabolites of vitamin A. ATRA plays a crucial role in the regulation of cellular proliferation, differentiation, and normal keratinization of ocular surface epithelium. ATRA has a potential therapeutic effect against some ocular surface cicatricial disorders such as Stevens-Johnson syndrome and diseases associated with corneal epithelial damage. ATRA is a promising tool in the treatment of allogenic graft rejection after penetrating keratoplasty and partial limbal stem cell deficiency (LSCD).   (Int Rev Ophthalmol,  2017,  41:  28-31)