Abstract:

The structure of proteins is closely related to their biological functions. In addition to the X-ray diffraction and nuclear magnetic resonance imaging methods, the application of cryo-electron microscopy has greatly promoted the development of structural biology. The protein concentration within human lens is the highest of any tissue in the body. Therefore, lens have the great advantage in the study of protein related research. Recent studies have revealed certain essential structural domains and related biological functions of crystallins. The spatial configuration of the lens protein is gradually progressing under the advancement of analytical techniques in structural biology.