Abstract:

Peroxisome proliferators-activated receptor-γ (PPAR-γ) is a member of the nuclear receptor superfamily. It has the ability of regulating lipid and glucose metabolization, anti-inflammatory and inhibition of autoimmunity. PPAR-γ may be effective for treating dry eye through limiting the production of inflammatory factors of the lacrimal gland, participating in development and aging of the meibomian gland, inhibition of  inflammation of the conjunctiva and controlling diabetes and Sjgren’s syndrome. (Int Rev Ophthalmol, 2018, 42:   371-375)