Abstract:

Familial vitreous amyloidosis(FVA) is a rare autosomal dominant genetic disease in which certain molecular gene mutations cause the corresponding proteins to denature, forming insoluble amyloids deposit in vitreous，resulting in a gradual decline in visual function. The transthyretin（TTR） mutation is the most common type of gene mutation. FVA is a rare disease of vitreous degeneration, whose diagnosis depends on the Congo red staining positive reaction of the intraoperative vitreous specimen. Vitrectomy is the most direct and effective treatment. (Int Rev Ophthalmol, 2018, 42:   401-405)