国际眼科纵览

• 综述 • 上一篇    下一篇

角膜胶原交联术及不同交联剂的研究进展

杨磊1 田磊2 张海霞3   

  1. 1 首都医科大学基础医学院 100069;2 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 眼科学与视觉科学北京市重点实验室 100005;3 首都医科大学生物医学工程学院 临床生物力学应用基础研究北京市重点实验室 100069
  • 收稿日期:2018-12-03 出版日期:2019-02-22 发布日期:2019-03-05
  • 通讯作者: 张海霞,Email:zhanghx@ccmu.edu.cn E-mail:zhanghx@ccmu.edu.cn
  • 基金资助:

    国家自然科学基金(31470914;31600758);北京市自然科学基金(7174287)

Progress in corneal collagen cross\|linking with different cross-linking agentia

Yang Lei1, Tian Lei2, Zhang Haixia3   

  1. 1 School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; 2 Beijing Institute of Ophthalmology, Beijing Tongren Eye Centre, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China; 3 School of Biomedical Engineering, Capital Medical University, Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Beijing 100069, China
  • Received:2018-12-03 Online:2019-02-22 Published:2019-03-05
  • Contact: Zhang Haixia, Email: zhanghx@ccmu.edu.cn E-mail:zhanghx@ccmu.edu.cn
  • Supported by:

    National Natural Science Foundation of China (31470914;31600758); Beijing Natural Science Foundation (7174287)

摘要:

角膜胶原交联术是治疗圆锥角膜的有效手段之一,通过角膜交联剂与光照射提高角膜强度,遏制或延缓圆锥角膜进行性发展。基于传统核黄素紫外光交联的创新术式和基于不同交联剂的交联方式不断涌现,包括跨上皮、快速核黄素紫外光交联,玫瑰红绿光交联、京尼平交联和甘油醛交联等。对于以上交联术式和不同交联剂的研究均致力于增加治疗效果和减少患者不适,研究结果将为临床上选择合适的角膜胶原交联术式治疗圆锥角膜提供理论基础和临床依据。

Abstract:

Corneal collagen cross-linking(CXL) is one of the effective methods for treating keratoconus, which enhances corneal strength with CXL agentia and light irradiation. CXL with riboflavin and ultraviolet\|A has been widely adopted in clinical for many years, which has preferable efficacy and safety. Based on traditional UVA and different cross\|linking agentia, there are more and more innovative techniques appear constantly, including transepithelial, rapid-CXL, Rose Bengal with green light, Genipin, Glyceraldehyde CXL and so on. These new techniques are aiming to increase the treatment effect and reduce patient malaise, and they provide a theoretical and clinical basis for the selection of appropriate CXL treatment of keratoconus.