国际眼科纵览

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光动力疗法在细菌性角膜炎治疗中的应用

苏冠羽,王乐滢,李彬,梁庆丰   

  1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科研究所 眼科学与视觉科学北京市重点实验室 100005
  • 收稿日期:2019-02-27 出版日期:2019-06-22 发布日期:2019-06-25
  • 通讯作者: 梁庆丰,Email:lqflucky@163.com
  • 基金资助:
    国家自然科学基金面上项目(81470607);北京市卫生系统高层次卫生技术人才培养基金(2014-3-016)

Application of photodynamic therapy in the treatment of bacterial keratitis

Su Guanyu, Wang Leying, Li Bin, Liang Qingfeng   

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China
  • Received:2019-02-27 Online:2019-06-22 Published:2019-06-25
  • Contact: Liang Qingfeng, Email: lqflucky@163.com
  • Supported by:
    National Natural Science Foundation of China (81470607); High-Level Talents in Beijing Health Bureau, China (2014-3-016)

摘要: 光动力疗法(photodynamic therapy,PDT)已经广泛应用于皮肤科、口腔科、肿瘤科等领域,其对病原微生物具有一定的杀伤作用,可将其应用于感染性疾病。在PDT应用于感染性角膜疾病的治疗中发现,其在体外和体内对细菌均有明显的杀灭作用,通过一定波长的光波联合特定光敏剂抑制细菌生长,对细菌性角膜炎有一定的治疗作用。不同波长光源联合不同化学成分光敏剂对细菌角膜炎效果不一。此方法也可部分解决临床治疗中的细菌耐药性问题。(国际眼科纵览,2019, 43:145-150)

Abstract: Photodynamic therapy(PDT) has been widely used in dermatology, dental, oncology and other fields. It has a certain killing effect on pathogenic microorganisms, and can be applied to infectious diseases. In the treatment for infectious corneal diseases, PDT has been found with significant killing effect on bacteria in vitro and in vivo. It inhibits bacterial growth by combining certain wavelengths of light waves with specific photosensitizers, demonstrating certain therapeutic effects on bacterial keratitis. Different wavelengths of light source combined with different chemical ingredient photosensitizers have different effects on bacterial keratitis. This method can also partially solve the problem of bacterial resistance in clinical treatment.(Int Rev Ophthalmol, 2019, 43: 145-150)