Abstract: microRNAs (miRNAs) are endogenous, noncoding single strand RNA with about 22 nucleotides. They inhibit gene translation through base pairing with mRNA (ususlly 3’ UTR) and play an important role in maintaining normal development, differentiation, apoptosis and physiological function of all tissues and organs．miRNAs are the hot spot of the life science recently. More and more researches had shown that miRNAs had specific expression in eye tissues, in which there were at least 250 kinds of miRNAs expressed in retina and affected its functions and diseases. This article reviews the research advances on the expression and function of miRNAs in retinopathy.