Abstract: 【Abstract】Thyroid associated ophthalmopathy (TAO) is an autoimmune disease causing proptosis, eyelid retraction, motility disorders with diplopia, corneal damage, compressed optic nerve and so on. Researchers found that physical discomfort, facial disfigurement and impaired visual function caused by TAO have a negative impact on patients’ employment, daily life, psychosocial function and their quality of life(QOL), using general healthrelated QOL questionnaires, visionspecific questionnaires and diseasespecific QOL questionnaires. Intervening measures, including surgery, intravenous methylprednisolone, orbital radiotherapy and so on, could improve patients' QOL, but not satisfying. In this review, we assess the evidence of the impact on patients’ QOL, improving means and the social care of TAO. (Int Rev Ophthalmol, 2012, 36: 331336)