Abstract: 【Abstract】Due to the unique anatomy and physiology of the eye, it is a challenge for scientists to design a drug delivery system. Ocular structure barriers, dynamic barriers and efflux pumps restrict the delivery and the effectiveness of drugs. Exploration of novel drug delivery strategies draws attention towards effective treatment. The recent progress and developments in the field of ophthalmic drug delivery, including colloidal systems such as liposomes, microemulsions; microsomal systems such as microparticle, nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers; gelforming systems such as bioadhesion gel, in situ gel and implants systems such as inserts and intraocular implants, etc. (Int Rev Ophthalmol, 2012, 36: 361-368）