Abstract: 【Abstract】Aging is a common feature of biological changes in the eye, especially in the Bruch membrane. It is recognized that Bruch membrane changes with the increase of age. Aging may be an important event to contribute to the pathogenesis of macular diseases, such as agerelated macular degeneration (AMD). Therefore, this review summarizes the latest concepts about the changes of anatomic structure, physiological function, lipids deposition on Bruch membrane with age, these factors may play an important role in the macular diseases. Further study on these factors will offer new ideas about the etiology, pathology, diagnose and treatment of macular diseases.  (Int Rev Ophthalmol, 2012, 36: 387-391）