Abstract: 【Abstract】Posterior capsular opacification (PCO) is caused by proliferation, migration and epithelialmesenchymal transition (EMT) of residual lens epithelial cells (LEC) in the equatorial region of capsule after cataract surgery, which influences the recovery of visual acuity and the improvement of visual quality after operation. Recently some researches demonstrate LEC express various types of chloride channels, and chloride channel is one kind of the most important anion channels in an organism that take part in electric activity, and also have a close relation with cell volume, proliferation, differentiation and migration. This paper bases on the newest research in volumeregulated chloride channel and introduce relationship between the pathogenesis of posterior capsular opacification and its molecular construction and physical function in order to provide new clues for future therapy of PCO. (Int Rev Ophthalmol, 2012, 36: 428-432）