Abstract: Congenital cataracts are the most common cause of treatable childhood blindness, onethird of which are inherited. More and more studies identify many mutations cause diseases because of mRNA aberrant splicing rather than altering protein sequences. Mutations can cause mRNA aberrant splicing through interfering the constitutive splice sites and alternative splice sites, disturbing some splice  components and alternative splicing regulatory factors. Studies show that mutations result congenital cataracts through interfering constitutive splice site. In this article, we will discuss the relationships between congenital cataract and mRNA aberrant splicing.