Abstract: Alzheimer’s disease (AD),   a devastating neurodegenerative disease, is the primary cause of dementia with no cure available. Amyloid plaques and neurofibrillary tangles underlie the two pathological hallmarks in AD brain. In addition to cognitive and behavioral deficits, vision abnormalities are prevalent in AD patients. While most AD related pathology occurs in the brain, the disease has also been reported to affect the retina, which is more accessible for imaging than the brain. Therefore, studying ADrelated retinal degeneration is a promising way for the investigation on AD pathologies and therapies that would eventually benefit the brain and cellular mechanisms in other retinal degenerations such as glaucoma and agerelated macular degeneration.