国际眼科纵览 ›› 2013, Vol. 37 ›› Issue (4): 284-288.doi: 103706/ cma.j.issn.16735803201304015

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氧化应激在葡萄膜炎发病机制中作用的研究进展

杨婷婷 邓娟   

  1. 510630 广州,中山大学附属第三医院眼科
  • 收稿日期:2013-05-23 出版日期:2013-08-22 发布日期:2013-09-03
  • 通讯作者: 邓娟, Email:viviadeng@163.com E-mail:viviadeng@163.com

Oxidative stress in uveitis

YANG Ting-ting, DENG Juan   

  1. Department of Ophthalmology, The Third Affiliated Hospital of Sunyat Sen University, Guangzhou 510630, China
  • Received:2013-05-23 Online:2013-08-22 Published:2013-09-03
  • Contact: DENG Juan,Email:viviadeng@163.com E-mail:viviadeng@163.com

摘要: 近来研究发现氧化应激产生的活性自由基是与葡萄膜炎发生相关的细胞因子和趋化因子的必须介质。氧化应激在非感染性和感染性葡萄膜炎发生和发展中均起了关键作用,调节或控制氧化应激有助于改善葡萄膜炎的症状。各种抗氧化剂通过不同的作用机制,如抑制氧化应激的产生,减少氧化应激的损伤,增强机体自身的抗氧化功能,达到治疗葡萄膜炎的目的。抗氧化治疗将可能是葡萄膜炎治疗的新策略。

Abstract: Active free radicals produced following the oxidative stress have been found recently to be a requisite medium of cytokines and chemokines associated with uveitis. Oxidative stress plays a key role in infectious and non infective uveitis. Regulating or controlling oxidative stress could alleviate the symptoms of uveitis. Various antioxidants  treat uveitis through different mechanisms, such as inhibiting oxidative stress, reducing oxidative stress damage or enhancing  antioxidant capability of the organism. Antioxidant will be a new strategy for the treatment of uveitis.