国际眼科纵览 ›› 2014, Vol. 38 ›› Issue (5): 356-360.doi: 10.3760/ cma. j. issn.1673-5803.2014.05.014

• 综述 • 上一篇    下一篇

糖尿病视网膜病变的炎症机制

郭荣花  程浩   

  1. 510120 广州,广州医科大学附属第一医院眼科
  • 收稿日期:2014-04-15 出版日期:2014-10-22 发布日期:2014-10-24
  • 通讯作者: 程浩,Email:chrischenghao@sina.com
  • 基金资助:

    广东省科技计划项目(2011B031800112)

Inflammatory machenism in the pathogenesis of diabetic retinopathy

GUO Rong-hua, CHENG Hao.   

  1. Department of Ophthalmology, the First Hospital, Guangzhou Meidical University, Guangzhou 510120, China
  • Received:2014-04-15 Online:2014-10-22 Published:2014-10-24
  • Contact: CHENG Hao, Email: chrischenghao@sina.com

摘要: 糖尿病视网膜病变(diabetic retinopathy,DR)是50岁以上人群主要致盲眼病之一。研究表明,DR的发生与非酶糖基化作用、蛋白激酶C激活、免疫/炎症、多元醇旁路、生长因子、氧化应激、RAS系统及血流动力学改变等假说有关,但其确切机制尚未完全阐明。近年来,炎症机制在DR发生发展中的作用一直受到国内外学者的关注,而肿瘤坏死因子α(TNFα)、黏附分子及血管内皮生长因子(VEGF)、色素上皮衍生因子(PEDF)在糖尿病视网膜病变发病机制中的作用更是研究的热点。本文就炎症因子及炎症相关因子在DR发病机制中作用的研究现状进行综述。(国际眼科纵览, 2014, 38: 356-后插I)    

Abstract: Diabetic retinopathy (DR) is the most common retinal vascular disease and one of the main blinding diseases for people over the age of 50 In recent years, studies have shown that the occurrence of DR is related with several hypothesis such as nonenzymatic glycosylation, activation of protein kinase C, immune or inflammation, polyol pathway, growth factors, oxidative stress/the renninangiotensin system and hemodynamic changes, but the exact mechanism has not been fully elucidated. Recently, the role of inflammatory factors in the development of DR has been attracting the attention of scholars both at domestic and abroad, particularlly the tumor necrosis factor alpha (TNFα), adhesion molecules,vascular endothelial growth factor(VEGF), pigment epitheliumderived factor (PEDF).This article reviews the current studies about the role of inflammatory factors and inflammatory related factors in the pathogenesis of DR.  (Int Rev Ophthalmol, 2014, 38:   356-Posterior I)