Abstract: Choroid neovascularization (CNV) has become one of the difficult problems in ophthalmology. Preparation of a stable CNV animal model for studying the pathogenesis and treatment of CNV has a profound significance now. Currently, CNV models can be induced with a laser, growth factor induction, or in the setting of transgenic mice, and they are all based on destruction of Bruch’s membrane by laser or overproduction of vascular endothelial growth factor. There are commonly used experimental model of animals since the recent: mouse, rabbit, pig and primate. Since a variety of model animals with different physiological characteristics, with different pathological changes in different animal models, the most suitable experimental animals should be choose based on different experimental needs.  (Int Rev Ophthalmol, 2014, 38: 118-122)