Abstract: Atropine is the antagonist of muscarinic receptor. 1% atropine was found to be able to inhibit myopia progression long ago. However, its usage was restricted due to the frequently happened side effects, such as photophobia and near vision blur. Recently, the focus of researchers shifted to the lowconcentration atropine, which was demonstrated to have effects of slowing the progression of myopia. Compared to 1% atropine, the effect of lowconcentration atropine is more sustained and durable, and the incidence of side effect is much more less.