Abstract:  Diabetic retinopathy (DR) is a progressive visionthreatening complication of diabetes mellitus, but its exact pathogenic mechanism is still less clear.The interactions of advanced gycation end products (AGEs) with its recptor (RAGE) induce the oxidative stress, vascular inflammation response, and predispose angiogenesis, all of which play essential roles in diabetic vascular complications.Therefore, inhibition of AGEs formation, blockade of AGEs crosslink and interaction of AGEs with RAGE may postpone the progression of DR.The article mainly sumarrizes the relationship between AGEs-RAGE system and DR, and the drug therapy of DR.