Abstract: Thyroid\|associated ophthalmopathy (TAO) is also called Graves’ ophthalmopathy (GO). It is an organ specific autoimmune disease, most patients experience two stages：  activity and stable. Assessment of the activity of TAO is of great important for its diagnosis in clinic. In current, we still lack of an accurate and specific method to determine the activity of TAO. Combining the three methods, the clinical activity score, single photon emission computed tomography (SPECT)/CT images, and the tear cytokines, help us to measure the activity degree of eye inflammation accurately, and benefit to giving the right choice of the treatment and then controlling the disease development timely. Three dimensional conformal orbital radiotherapy is the first\|line treatment for moderate\|to\|severe TAO. And it is recommended to combined with glucocorticoids because of the increasing efficacy and reducing side effects.