国际眼科纵览 ›› 2021, Vol. 45 ›› Issue (1): 38-43.doi: 10.3760/cma.j.issn.1673-5803.2021.01.008

• 综述 • 上一篇    下一篇

睑缘炎相关角结膜炎的治疗进展

陈君语 潘志强   

  1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 眼科学与视觉科学北京市重点实验室100730
  • 收稿日期:2020-04-12 出版日期:2021-02-22 发布日期:2021-02-22
  • 通讯作者: 潘志强,Email:panyj0526@sina.com E-mail:panyj0526@sina.com

Progress on treatment of blepharokeratoconjunctivitis

Chen Junyu, Pan Zhiqiang   

  1. Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
  • Received:2020-04-12 Online:2021-02-22 Published:2021-02-22
  • Contact: Pan Zhiqiang, Email: panyj0526@sina.com E-mail:panyj0526@sina.com

摘要: 睑缘炎相关角结膜炎(blepharokeratoconjunctivitis,BKC)是临床上常见的一类慢性眼表疾病,常累及结膜和角膜,对患者的视力造成严重威胁。由于其起病隐匿且临床表现及体征易与其他角结膜炎性疾病相混淆,从而容易造成误诊、漏诊,尤其对于儿童患者可导致弱视或更严重的视力损害。BKC的治疗首先需要控制睑缘炎症,以局部治疗为主,病情较重的患者,可加用口服药物系统治疗。而对于角结膜炎症,可以加用非甾体抗炎药、糖皮质激素、免疫抑制剂等。临床上轻度BKC选用低浓度糖皮质激素或非甾体抗炎药治疗;中重度BKC选用高浓度糖皮质激素或低浓度糖皮质激素联合免疫抑制剂,角膜溃疡者需加用抗菌药物眼膏;严重者可能需要手术治疗。

关键词: 睑缘炎, 角膜结膜炎, 治疗

Abstract: Blepharokeratoconjunctivitis (BKC) refers to a group of chronic ocular surface diseases, which often involves the conjunctiva and cornea, and causes severe vision impairment. It’s easy to be misdiagnosed and missed diagnosed, because its onset is insidious and its clinical manifestations and signs are easily confused with other corneal and conjunctival diseases. It can cause amblyopia or severe visual impairment, especially for pediatric population. The treatment of BKC needs to control the inflammation of the eyelid margin first, with local treatment as the mainstay. Patients with severe disease, oral drug can be added. Non-steroidal anti-inflammatory drugs, glucocorticoids, immunosuppressants, can be added for corneal and conjunctival inflammation. Mild BKC should be treated with low\|concentration glucocorticoids or non-steroidal anti-inflammatory drugs. Moderate-to-severe BKC should be treated with high-concentration glucocorticoids or low-concentration glucocorticoids combined with immunosuppressive agents. Those with corneal ulcers need to use antibacterial eye ointments. Severe cases may require surgery.

Key words: blepharitis, keratoconjunctivitis, treatment