睑板腺功能障碍患者眼表微生物菌群变化的研究

doi:10.3760/ cma.j.issn.1673-5803.2022.04.006

国际眼科纵览 ›› 2022, Vol. 46 ›› Issue (4): 324-327.doi: 10.3760/ cma.j.issn.1673-5803.2022.04.006

睑板腺功能障碍患者眼表微生物菌群变化的研究

包郑伊琳^1,2张文佳^1,2黄悦^1,2胡竹林²

¹昆明医科大学 650000；²云南大学附属医院眼科，昆明 650000

收稿日期:2021-10-25 出版日期:2022-08-22 发布日期:2022-08-22
通讯作者: 胡竹林，Email：hzl@263.net
基金资助:
昆明医科大学应用基础研究联合专项（202001AY070001-255）；云南省卫生健康委员会医学领军人才培养计划（L-2019029）

Research on the changes of ocular surface microorganisms in meibomian gland dysfunction patients

Bao Zhengyilin^1,2, Zhang Wenjia^1,2, Huang Yue ^1,2, Hu Zhulin²

¹Kunming Medical University, Kunming 650000, China;²Department of Ophthalmology, Affiliated Hospital of Yunnan University, Kunming 650000, China

Received:2021-10-25 Online:2022-08-22 Published:2022-08-22
Contact: Hu Zhulin, Email: hzl@263.net
Supported by:
Applied Basic Research Joint Project of Kunming Medical University (202001AY070001-255); Medical Leading Talents Training Plan of Yunnan Health Commission(L-2019029)

摘要/Abstract

摘要： 睑板腺功能障碍（meibomian gland dysfunction，MGD）与眼表微生物菌群关系紧密，眼表微生物菌群种类及数量的变化是MGD的诱因或加重因素。MGD患者眼表存在多种潜在致病菌株，如凝固酶阴性葡萄球菌、痤疮丙酸杆菌以及棒状杆菌等，其眼表微生物较强的免疫逃逸以及毒性作用影响MGD患者眼表的免疫反应。此外，眼表微生物具有脂肪酶及蛋白酶活性，影响睑板腺睑脂的分泌及抗炎反应，加重MGD。（国际眼科纵览，2022, 46：324-327）

关键词: 睑板腺功能障碍, 微生物组, 病原体, 菌群

Abstract: Meibomian gland dysfunction (MGD) is closely related to ocular surface microorganisms. The changes in the species and quantity of ocular surface microorganisms are the inducement or aggravating factors of MGD. There are many potential pathogenic strains on the ocular surface in MGD patients, such as coagulate negative staphylococcus, propionibacterium acnes, and corynebacterium and so on. The strong immune escape and toxicity of ocular surface microorganisms affect the immune response of MGD patients. In addition, the microorganisms on the eye surface have lipase and protease activities, which affect the secretion and anti-inflammatory response of eyelid fat in meibomian gland, and aggravate the condition of MGD patients.(Int Rev Ophthalmol, 2022, 46: 324-327)

Key words: Meibomian gland dysfunction, microbiome, pathogen, bacteria flora

包郑伊琳张文佳黄悦胡竹林. 睑板腺功能障碍患者眼表微生物菌群变化的研究[J]. 国际眼科纵览, 2022, 46(4): 324-327.

Bao Zhengyilin Zhang Wenjia Huang Yue Hu Zhulin. Research on the changes of ocular surface microorganisms in meibomian gland dysfunction patients[J]. International Review of Ophthalmology, 2022, 46(4): 324-327.

睑板腺功能障碍患者眼表微生物菌群变化的研究

Research on the changes of ocular surface microorganisms in meibomian gland dysfunction patients

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