白细胞介素与脉络膜新生血管形成的关系

doi:10.3760/ cma.j.issn.1673-5803.2023.01.016

国际眼科纵览 ›› 2023, Vol. 47 ›› Issue (1): 84-91.doi: 10.3760/ cma.j.issn.1673-5803.2023.01.016

白细胞介素与脉络膜新生血管形成的关系

张吴越^{1, 2} 桑爱民¹

1 南通大学附属医院眼科 226000；2 南通大学医学院 226000

收稿日期:2022-06-04 出版日期:2023-02-22 发布日期:2023-03-11
通讯作者: 桑爱民，Email：sangam@ntu.edu.cn E-mail:sangam@ntu.edu.cn
基金资助:
江苏省研究生科研创新计划（KYCX21_3115）

Interleukins and choroidal neovascularization

Zhang Wuyue^1,2, Sang Aimin¹

1 Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226000, China; 2 Nantong University, Nantong 226000, China

Received:2022-06-04 Online:2023-02-22 Published:2023-03-11
Contact: Sang Aimin, Email: sangam@ntu.edu.cn E-mail:sangam@ntu.edu.cn
Supported by:
Jiangsu Graduate Scientific Research Innovation Program (KYCX21_3115)

摘要/Abstract

摘要： 脉络膜新生血管形成（choroidal neovascularization，CNV）是各种脉络膜视网膜疾病常见的病理终点，是视力不可逆损害的主要病因。CNV是一个非常复杂的病理生理过程，涉及多种结构细胞、炎性细胞及炎性因子，与视网膜局部慢性炎症有关。研究表明，作为炎性细胞因子一大家族的白细胞介素类（interluelin，IL），在不同的免疫微环境中通过调节促血管生成和抗血管生成因子的表达，参与CNV的发生发展，调节IL的生成及功能可能作为潜在的治疗靶点。（国际眼科纵览，2023, 47：84-91）

关键词: 白细胞介素, 脉络膜新生血管形成

Abstract: Choroidal neovascularization (CNV) is a common pathological endpoint of various choroidal retinal diseases and the main cause of irreversible visual impairment in humans. The formation of CNV is a very complex pathophysiological process involving a variety of structural cells, inflammatory cells and inflammatory factors, and is related to local chronic inflammation of the retina. Studies have shown that interleukins (ILs), as a large family of inflammatory cytokines, participate in the occurrence and development of CNV by regulating the expression of pro-angiogenic and anti-angiogenic factors in different immune microenvironments, and regulating the generation and function of ILs may serve as potential therapeutic targets. (Int Rev Ophthalmol, 2023, 47: 84-91)

Key words: interleukins, choroidal neovascularization

张吴越, 桑爱民. 白细胞介素与脉络膜新生血管形成的关系[J]. 国际眼科纵览, 2023, 47(1): 84-91.

Zhang Wuyue, Sang Aimin. Interleukins and choroidal neovascularization[J]. International Review of Ophthalmology, 2023, 47(1): 84-91.

[1]	苏彦刘芳. CD40信号通路与脉络膜新生血管形成的关系[J]. 国际眼科纵览, 2012, 36(3): 182-188.
[2]	侯慧媛梁宏亮王雨生. 干细胞疗法及其在脉络膜新生血管治疗中的应用前景[J]. 国际眼科纵览, 2012, 36(3): 177-182.

白细胞介素与脉络膜新生血管形成的关系

Interleukins and choroidal neovascularization

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