关键词: 外泌体, 葡萄膜黑色素瘤, 视网膜母细胞瘤, 转移

Abstract: Exosome, a kind of small vesicle enclosed by a phospholipid bilayer, is secreted by cells. Exosomes carry many biological molecules, such as protein, DNA, mRNA, miRNA, lipid, which are mediators of intercellular communication. Exosomes play an important role in many tumor pathological processes such as invasion and metastasis, chemical resistance, angiogenesis, and immune escape. Recent studies have found that exosomes exist in the serum, vitreous body, tumor tissue and tumor cell lines cultured in vitro of patients with uveal melanoma (UM) and retinoblastoma (RB), and are involved in the metastasis and malignancy of these two tumors.  (Int Rev Ophthalmol, 2024, 48:  151-155)

Key words: exosome, uveal melanoma, retinoblastoma, metastasis