Abstract:

Ubiquitination is the process by which ubiquitin is covalently attached to substrate proteins through multistage enzymatic reactions. When the aggregated ubiquitinated proteins are overloaded and cannot be cleaned up in time, the health and viability of cells will be threatened. However, the ubiquitination and degradation of some key proteins may cause related diseases. In this review, we summarize the research progress on the degradation mechanisms of ubiquitinated proteins in ophthalmic diseases, in order to provide new ideas and strategies for clinical diagnosis and treatment.(Int Rev Ophthalmol, 2020, 44：366-372)

Key words: ubiquitination, degradation, ophthalmic diseases