International Review of Ophthalmology ›› 2025, Vol. 49 ›› Issue (1): 75-80.doi: 10.3760/cma.j.cn115500-20241113-01013

Previous Articles    

The correlation between matrix metalloproteinase 2 and ophthalmic diseases

Abudou Sataer Aishan1,2, Zhou Ying2,Wang Xiaokang2, Li Xia2   

  1. 1 Graduate School, Xinjiang Medical University, Urumqi 830054, China;2 Department of Ophthalmology, Xinjiang 474 Hospital，Urumqi  830013, China
  • Received:2024-11-13 Online:2025-02-22 Published:2025-02-20
  • Contact: Li Xia, Email:Lilixia5010@sina.com
  • Supported by:
     Xinjiang Uyghur Autonomous Region Natural Science Foundation (2024D01A100); Xinjiang Military Region General Hospital Bejing Road Medical Zone Key Holding Research Project (2022jzbjl18); Science and Technology Plan Project of Urumqi City (202461) and the project of Xinjiang 474 Hospital (2023xj474001).

Abstract: Matrix metalloproteinase (MMP) has a class of protein hydrolases that degrade the extracellular matrix. In corneal diseases, matrix metalloproteinase 2 (MMP-2) is associated with migration and infiltration of inflammatory cells, thereby exacerbating the inflammatory response and tissue damage in corneal alkali burns. In glaucoma, MMP-2 maintains normal aqueous humor dynamic balance by regulating the extracellular matrix. However, after glaucoma filtration surgery, MMP-2 can promote bleb fibrosis, increase bleb resistance, and hinder the outflow of aqueous humor, thus affecting the surgical effect. (Int Rev Ophthalmol, 2025, 49:  75-80)

Key words: matrix metalloproteinase 2, ophthalmic diseases , glaucoma ；lens zonule