Abstract: The development and transformation of anisometropia is a complex process that is often affected by many factors. Hyperopia induced anisometropia is relatively stable, while myopic anisometropia has more complex changes. Amblyopia has a significant impact on the development of anisometropia. Before the age of 6, myopic anisometropia tends to decrease, and then stabilizes or slowly increases. Single focus frame glasses stabilize the degree of refractive error, but increase myopia in both eyes. Functional frame glasses stabilize the degree of anisometropia and achieve good myopia control. Orthokeratology has a better effect on controlling myopia in high myopia degree eyes, increasing myopia in the contralateral eye and reducing the degree of unevenness. The impact of atropine preparations on the development and outcome of anisometropia remains to be studied. (Int Rev Ophthalmol, 2025, 49:  158-160，Cover III)

Key words: anisometropia, refraction change