Abstract: Ocular graft-versus-host disease (oGVHD) is an immune disease that occurs in the eye after allogeneic hematopoietic stem cell transplantation, which seriously affects the vision and quality of life of patients. Current treatment modalities are inadequate, and new treatment options and targets are needed to improve the therapeutic efficacy of oGVHD. In recent years, a large number of studies have shown that exosomes, as important mediators of cell-to-cell communication, have shown important value in the pathogenesis, diagnosis and treatment of oGVHD. This article reviews the research progress of exosomes from different sources in oGVHD.

Key words: Ocular graft-versus-host disease, Exosomes, Immunomodulation