Abstract:

Oxidative stress is a common injury mechanism in the development of diabetic retinopathy (DR). Antioxidants, as inhibitors of oxidative stress, play a certain role in the prevention and protection of DR.Natural antioxidants exist in plants or food, which have the advantages of easy access, easy acceptance by patients, low side effects, and partial dietary access to prevent the progression of DR. Therefore, they have become the first choice for the research on the use of antioxidants to prevent and delay DR. Recent studies have found that most antioxidants play an antioxidant role through the Nrf2 signaling pathway, but the specific mechanism of action is different due to the complexity of the upstream and downstream proteins of the signaling pathway, so the specific mechanism of action of various antioxidants in DR remains to be further studied. (Int Rev Ophthalmol, 2019, 43: 377-384)