Abstract: Cell senescence refers to the attenuation of cell physiological functions, including phenomena such as decreased proliferation capacity, cell cycle arrest, cell apoptosis, and increased expression of senescence\|related genes. In recent years, with people's further understanding of aging and the continuous supplement and upgrade of cell aging detection methods, new ideas and new methods have been provided for clinical treatment of aging\|related diseases. At present, many ocular surface diseases are found to be related to aging, such as dry eye, meibomian gland dysfunction, conjunctiochalasis, Fuchs corneal endothelial dystrophy, pterygium and pinguecula. It suggests that the ocular surface diseases can be further understood, diagnosed and treated from the perspective of cell senescence.

Key words: cell senescence, ocular surface diseases, dry eye, meibomian gland dysfunction, conjunctivochalasis