Abstract: The pupillary light reflex is a potential functional sign of the afferent pathway of the retina and optic nerve. Abnormal pupillary light reflex or relative afferent pupillary disorder will arise when glaucoma patients develop asymmetrical optic neuropathy in one or both eyes. With the development of pupil detection equipment, the accuracy of detecting optic nerve damage in glaucoma based on pupil dynamic image recognition technology has improved a lot. This article reviews the application and progress of new pupil detection methods in glaucoma in recent years, evaluates the accuracy and development status of pupil accessing instruments for glaucoma detection, and provides a reference for exploring glaucoma screening approaches. (Int Rev Ophthalmol, 2021, 45: 152-157)

Key words: glaucoma/diagnosis, pupillary light reflex