International Review of Ophthalmology ›› 2021, Vol. 45 ›› Issue (3): 240-245.doi: 10.3760/cma.j.issn.1673-5803.2021.03.013

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Role of autophagy in the pathogenesis of corneal diseases

Yu Rui1, Gao Honglian2, Li Xinmeng1, Liu Qiqi1, Zhang Lei1   

  1. 1Department of Ophthalmology, the Affiliated Hospital of Binzhou Medical University, Shandong 256603, China；2Clinical Medical Laboratory of Affiliated Hospital of Binzhou Medical University, Shandong 256603, China

  • Received:2020-08-24 Online:2021-06-22 Published:2021-06-24
  • Contact: Zhang Lei, Email: zhangleisd@263.net
  • Supported by:
    Development Project of Medicine and Health Science Technology of Shandong Province（2016WS0022）

Abstract: Autophagy is a highly conservative process of material cycle in eukaryotic cells and plays an important role in the survival and maintenance of cells. Autophagy makes an important impact in the development of corneal diseases such as keratoconus, dry eye, herpes simplex keratitis, Fuchs corneal endothelial dystrophy, granular corneal dystrophy type 2, etc. However, its role in corneal neovascularization and fibrosis remains unclear.(Int Rev Ophthalmol, 2021, 45: 240-245)


Key words: autophagy, corneal diseases, fibrosis