International Review of Ophthalmology ›› 2021, Vol. 45 ›› Issue (3): 246-250.doi: 10.3760/cma.j.issn.1673-5803.2021.03.014

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MicroRNA and corneal wound healing

Liu Yuxin1,2, Wang Liqiang2    

  1. 1Nankai University, Tianjin 300071, China; 2Department of Ophthalmology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

  • Received:2020-07-25 Online:2021-06-22 Published:2021-06-22
  • Contact: Wang Liqiang, Email: liqiangw301@163.com
  • Supported by:
    National Key R&D Program of China (2017YF0103204); National Natural Science Foundation of China (81670830， 81770887)

Abstract: MicroRNA has a critical role in corneal wound healing. A complex and regulated sequence of cellular reactions involve cell death, migration, proliferation, differentiation, and extracellular matrix remodeling. Distributed in different levels of cornea, microRNA is a key regulator in growth factors, cytokines and signaling pathways downstream. Variety of microRNAs simultaneously modulates multiple signaling pathways and represents a complex and precise regulatory network to participate in the cascade reaction of corneal wound healing. Meanwhile, the deposition of extracellular matrix and the angiogenesis caused by the altered microRNA expression indicates the importance of microRNA in corneal pathological repair.(Int Rev Ophthalmol, 2021, 45: 246-250)


Key words: microRNA, cornea injury, wound healing