International Review of Ophthalmology ›› 2021, Vol. 45 ›› Issue (6): 483-487.doi: 10.3760/cma.j.issn.1673-5803.2021.06.004

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Role of glial cells in the occurrence and development of diabetic retinopathy

Lin Peijie, Zhao Qian, Fan Wei, Lai Mingying   

  1. Shenzhen Eye Hospital Affiliated to Jinan University, Shenzhen 518040, China

  • Received:2020-12-11 Online:2021-12-22 Published:2021-12-22
  • Contact: Lai Mingying, Email: laimydoc@163.com
  • Supported by:
    Shenzhen Science and Technology Plan Project(JCYJ201604283000225)

Abstract: The pathogenesis of diabetic retinopathy(DR) is still unclear. During the occurrence and development process of DR, retinal glial cells(including astrocytes, Müller cells and microglial cells) react becoming activated and undergo a series of changes: glial fibrillary acidic protein expression, decreased glutamic acid metabolism, up-regulated aldose reductase activity, increased oxidative stress, secretion of pro-inflammatory signals. Excessive activation of glial cells plays an important role in the DR course.(Int Rev Ophthalmol, 2021, 45: 483-487)


Key words: diabetic retinopathy, glial cells, astrocytes, Müller cells, microglial cells