The pathogenesis of keratoconus

doi:10.3760/cma.j.issn.1673-5803.2022.04.003

International Review of Ophthalmology ›› 2022, Vol. 46 ›› Issue (4): 304-309.doi: 10.3760/cma.j.issn.1673-5803.2022.04.003

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The pathogenesis of keratoconus

Ma Chunxia, Wang Yingwei, Zhou Jian

Department of Ophthalmology, Xijing Hospital, Air Force Military Medical University, Eye Institute of PLA, Xi'an 710032, China

Received:2021-12-24 Online:2022-08-22 Published:2022-08-22
Contact: Zhou Jian, Email: zhoujian@fmmu.edu.cn
Supported by:
Shaanxi Province Research and Development Project (2022SF-067)；Clinical Research Project of Air Force Military Medical University (2021LC2219)

Abstract

Abstract: Keratoconus is a disease characterized by corneal dilatation, thinning of central corneal stroma and conical protrusion. The pathogenesis is still unclear. The existing research on genetic genes mainly focuses on genome-wide association analysis, linkage analysis, candidate gene analysis and mitochondrial genome, and the enzymology research mainly focuses on lyases and inhibitory components. In addition, apoptosis, inflammatory reaction and chronic corneal injury (eye rubbing, wearing of corneal contact lenses, ultraviolet) are also related to the pathogenesis of keratoconus. (Int Rev Ophthalmol, 2022, 46: 304-309)

Key words: keratoconus, genetics, enzymology

Ma Chunxia, Wang Yingwei, Zhou Jian. The pathogenesis of keratoconus[J]. International Review of Ophthalmology, 2022, 46(4): 304-309.

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The pathogenesis of keratoconus

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