International Review of Ophthalmology ›› 2022, Vol. 46 ›› Issue (4): 361-366.doi: 10.3760/cma.j.issn.1673-5803.2022.04.014

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The role and mechanism of human immunodeficiency virus infection on the progression of age-related macular degeneration

Zhou Yamei, Zeng Jia, Liu Xiaojuan   

  1. Department of Pathogen Biology, Medical College, Nantong University, Jiangsu 226001, China
  • Received:2021-09-28 Online:2022-08-22 Published:2022-08-22
  • Contact: Liu Xiaojuan, Email: lxj@ntu.edu.cn
  • Supported by:
     Nantong Science and Technology Plan Project (MS22018009)

Abstract: Human immunodeficiency virus (HIV) is the causative agent of acquired immunodeficiency syndrome (AIDS). Epidemiological surveys have shown that the prevalence of age-related macular degeneration (AMD) in HIV infected people is higher than that in non HIV infected people. HIV down-regulates tight junction proteins in retinal pigment epithelium (RPE) cells, disrupting the blood-retinal barrier (BRB), and induce oxidative stress and inflammation in RPE cells through glycoprotein 120 (gp120) on the envelope surface and transactivator of transcription (Tat), resulting in the loss of photoreceptors, consequently promoting AMD progression. (Int Rev Ophthalmol, 2022, 46:  361-366)


Key words: human immunodeficiency virus, age-related macular degeneration