Mechanism of inflammatory response in posterior capsule opacification after cataract surgery in high myopia

doi:10.3760/cma.j.issn.1673-5803.2023.02.005

International Review of Ophthalmology ›› 2023, Vol. 47 ›› Issue (2): 121-125.doi: 10.3760/cma.j.issn.1673-5803.2023.02.005

Previous Articles Next Articles

Mechanism of inflammatory response in posterior capsule opacification after cataract surgery in high myopia

Ma Hui, Bao Yongzhen

Department of Ophthalmology, Peking University People’s Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, College of Optometry，Peking University Health Science Center, Beijing 100044, China

Received:2022-09-26 Online:2023-04-22 Published:2023-04-22
Contact: Bao Yongzhen, Email: drbaoyz@sina.com
Supported by:
Clinical Follow-up Study of Haoya (Shenzhen) Medical Device Consulting Co., Ltd(2119000332)

Abstract

Abstract: High myopia is a high risk factor for cataract and posterior capsule opacification (PCO) after cataract surgery. The occurrence time of PCO in high myopia is earlier, the degree is heavier, the treatment risk is higher. Previous studies have shown that inflammatory response plays an important role in the pathogenesis of high myopia and PCO, and the inflammatory microenvironment in high myopia seems to be closely related to the occurrence of PCO. The elevated levels of inflammatory factors such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), and matrix metalloproteinase-2 (MMP-2) in highly myopic eyes are involved in epithelial-mesenchymal transition and extracellular matrix contraction, which promotes the development of PCO.(Int Rev Ophthalmol, 2023, 47: 121-125)

Key words: high myopia, posterior capsule opacification, inflammatory response

Ma Hui, Bao Yongzhen. Mechanism of inflammatory response in posterior capsule opacification after cataract surgery in high myopia[J]. International Review of Ophthalmology, 2023, 47(2): 121-125.

[1]	Zhang Ye, Qi Jiao, Zhu Xiangjia. Postoperative complications of cataracts associated with high myopia [J]. International Review of Ophthalmology, 2025, 49(1): 13-18.
[2]	Cheng Quan, Zha Xu, Zhou Liqiong, Zhang Yuanping. The role of pyroptosis in the pathogenesis of diabetes retinopathy [J]. International Review of Ophthalmology, 2025, 49(1): 45-50.
[3]	Lin Leying, Lin Peijie, Lai Mingying. Relationship between high myopia and primary open angle glaucoma [J]. International Review of Ophthalmology, 2024, 48(3): 172-176.
[4]	Zheng Xin, Wan Xiuhua. Capsule polishing in cataract surgery to prevent posterior capsule opacification [J]. International Review of Ophthalmology, 2024, 48(3): 205-210.
[5]	Xu Su, Zhang Yuhang, Si Wei, Zhang Fengyan. The impact of regulatory factors on the TGF-β pathway on posterior capsule opacification [J]. International Review of Ophthalmology, 2024, 48(2): 87-92.
[6]	Bai Yang, Li Haoru, Sui Jinyuan, Wei Ruihua. The mechanism of pathogenesis and treatment of myopic traction maculopathy [J]. International Review of Ophthalmology, 2024, 48(1): 69-74.
[7]	Wu Jiale, Xiong Zhaohui, Xu Yincong, Sun Miaomiao, Gao Jie. Application of posterior scleral reinforcement surgery in the treatment of high myopia [J]. International Review of Ophthalmology, 2023, 47(6): 517-523.
[8]	Liu Jianying, Li Jing, Wan Xiuhua. Advances in surgical treatment of cataract with high myopia [J]. International Review of Ophthalmology, 2023, 47(6): 524-530.
[9]	Wang Gechun, , Yuan Fei. The relationship between dome-shaped macula and refractive state and common complications [J]. International Review of Ophthalmology, 2023, 47(4): 339-344.
[10]	Chen Dongjun, Wan Xiuhua. Application of capsular tension ring in cataract surgery [J]. International Review of Ophthalmology, 2023, 47(4): 315-321.
[11]	Du Xueyu, Yan Hong. Research progress on the safety and effectiveness of ICL implantation in the treatment of patients over 40 years of age with high myopia [J]. International Review of Ophthalmology, 2023, 47(3): 233-237.
[12]	Yao Ailin , Chu Yanhua. Research status of dome-shaped macula in high myopia [J]. International Review of Ophthalmology, 2023, 47(2): 131-137.
[13]	Ni Yan, Zheng Libin, Xu Yesheng, Yao Yufeng. The treatment of herpes simplex virus necrotizing stromal keratitis [J]. International Review of Ophthalmology, 2022, 46(3): 247-252.
[14]	Li Meng, Mao Yingyan, Wan Xiuhua. Intraocular lens modification for prevention of posterior capsule opacification [J]. International Review of Ophthalmology, 2022, 46(1): 22-28.
[15]	Min Yalan, Liu Weifeng. The structure and function of Bruch’s membrane and its relationship with myopia [J]. International Review of Ophthalmology, 2021, 45(3): 221-225.

Mechanism of inflammatory response in posterior capsule opacification after cataract surgery in high myopia

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments