Abstract: Antibacterial photodynamic therapy (aPDT) is a new treatment method, which uses radiation within a specific electromagnetic spectrum as a light source to activate photosensitizers enriched in the lesion and generate reactive oxygen radicals (ROS), and finally kill pathogenic microorganisms. Compared with traditional anti-infection therapy, aPDT shows the advantage of lower cytotoxicity, extremely low drug resistance and accurate localization. Because of the excellent optical properties of eyeballs, aPDT is especially suitable for the treatment of eye infections such as bacterial keratoconjunctivitis, viral keratitis, fungal keratitis, acanthamoeba keratitis and various infectious endophthalmitis.(Int Rev Ophthalmol, 2023, 47:  548-552)

Key words: photodynamic therapy, eye infection