Abstract:

On the basis of optical coherence tomography (OCT) technique, the formation and development of idiopathic macular hole (IMH) can be well observed. A bistable hypothesis of full\|thickness macular hole formation and closure has been postulated to explain this linkage of the morphological changes on the two sides of a full\|thickness macular hole. The continuous innovation of different internal limiting membrane (ILM) peeling during vitreous\|retinal surgery, such as the inverted internal limiting membrane flap technique, the foveola nonpeeling internal limiting membrane technique and the autologous transplantation of the internal limiting membrane technique, can make macular hole closed better and patient’s visual function improved. In recent years, the pharmacologic vitreolysis, especially ocriplasmin, has gradual progress in the prevention and treatment of IMH. In this article we review the current research in the mechanism and treatment of IMH.(Int Rev Ophthalmol,2015,39:351.356)