Abstract: Corneal collagen crosslinking (CXL) has been demonstrated to retard or arrest progression of the keratoconus, especially in the middle and early stages of the disease. So far, articles have shown that there was still a certain possibility of continuous progression post CXL. Factors of postoperative progression include that: criteria of postoperative progression, surgical protocol (epithelium-off or transepithelial CXL, drug-delivery of riboflavin, duration and pattern of ultraviolet A irradiation), age, cone location, preoperative Kmax value, eye rubbing and (or) allergies. Most articles suggested that the effect of preventing keratoconus progression were as follows: epithelium-off CXL >iontophoretic CXL >riboflavin penetration enhanced CXL, Dresden protocol >accelerated CXL, adult >pediatric, central cone >peripheral cone, preoperative low Kmax >preoperative high Kmax, no eye rubbing and allergy >combined with eye rubbing and (or) allergy. This paper will detail the above factors that influence the progression of the keratoconus after CXL and provide reference for clinical intervention and prognosis evaluation.