TGFβ-related signaling pathways in proliferative vitreoretinopathy

doi:10.3760/cma.j.issn.1673-5803.2021.05.017

International Review of Ophthalmology ›› 2021, Vol. 45 ›› Issue (5): 459-inside back cover.doi: 10.3760/cma.j.issn.1673-5803.2021.05.017

TGFβ-related signaling pathways in proliferative vitreoretinopathy

Zhang Wuyue, Sang Aimin

Department of Ophthalmology, the Affiliated Hospital of Nantong University, Nantong Jiangsu 226001, China

Received:2021-01-28 Online:2021-10-22 Published:2021-10-25
Contact: Sang Aimin, Email：sangam@ntu.edu.cn
Supported by:
Jiangsu Graduate Scientific Research Innovation Program (KYCX21_3115)

Abstract

Abstract: Proliferative vitreoretinopathy (PVR) is a common cause of failure and recurrence of retinal detachment surgery. The pathophysiological mechanism of PVR is complex, and TGF-β-mediated signaling pathway network plays an important role in the formation of PVR. In this paper, we reviewed the progress of TGF-β -mediated MAPK, Notch, Akt, BMP, RhoA/ROCK, PKA, and JAK/STAT signaling pathways in PVR, and illustrate their important roles in the formation of PVR, so as to provide a new idea for clinical treatment. (Int Rev Ophthalmol, 2020, 45：459-inside back cover)

Key words: transforming growth factor-β, proliferative vitreoretinopathy, retinal pigment epithelial cell

Zhang Wuyue, Sang Aimin. TGFβ-related signaling pathways in proliferative vitreoretinopathy[J]. International Review of Ophthalmology, 2021, 45(5): 459-inside back cover.

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TGFβ-related signaling pathways in proliferative vitreoretinopathy

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