Abstract: Lens regeneration refers to the process of inducing new lens tissue by constructing a suitable microenvironment for lens development in vitro or in vivo using stem cells as materials. Regenerated lens tissue can be used to establish biological model for drug testing or research the pathological changes of lens diseases, and it is expected to replace artificial lens implantation as a new choice for cataract treatment. At present, the research on it mainly focuses on three aspects: the signal pathway, lens regeneration in vitro and lens regeneration in situ. The Wnt pathway and cell polarity pathway have been further elucidated, human induced pluripotent stem cells have become a new option for in vitro lens regeneration, and the application of minimally invasive procedures has provided the necessary conditions for in situ lens regeneration. (Int Rev Ophthalmol, 2023, 47: 30-35)

Key words: lens regeneration, stem cells, signal pathway, cataract