Abstract: Borneol, a lipid-soluble terpenoid, which has a good selective permeation enhancement effect on hydrophilic and high molecular weight drugs by changing the tight junction structure between skin stratum corneum and loose endothelial cells. Additionally, borneol positively impacts the penetration of drugs in physiological eye tissue and pathological lesion tissues. It accomplishes this by loosening corneal epithelial cells, enabling the phospholipid bilayer to arrange in an orderly way and expanding the intercellular space, thus promoting infiltration and channel induction. Furthermore, borneol has the ability to regulate retinal vascular endothelial cells and tight junction proteins within the blood-eye barrier, corneal barrier, and retinal barrier. This modulation can enhance the therapeutic effects of various drugs used in the treatment of ocular diseases.

Key words: borneol/pharmacology, promoting permeability, blood-eye barrier