International Review of Ophthalmology ›› 2024, Vol. 48 ›› Issue (6): 411-415.doi: 10.3760/ cma.j.issn.1673-5803.2024.06.003

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Surface modification of intraocular lenses for the prevention and treatment of endophthalmitis

Zheng Xin, Wan Xiuhua   

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100730, China
  • Received:2022-10-19 Online:2024-12-22 Published:2024-12-06
  • Contact: Wan Xiuhua, Email: wanxh@ccmu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(82171037, 82471055); Beijing New-Star Plan Science and Technology Cross Cooperation Project(20240484565)

Abstract: The surface modification of intraocular lens (IOL) can effectively reduce the risk of endophthalmitis and postoperative infection associated with cataract surgery. According to the effect materials modified by IOL, the surface modification of IOL can be divided into two categories, drug loading and non-drug loading modification. Drug-loaded IOL surface modification can be achieved by "coating", such as critical fluid impregnation, polymer/pharmaceutical chemical coating technology and "immersion". Antibiotics such as moxifloxacin are loaded on the surface of IOL to prevent endophthalmitis. Surface hydrophilic modification of hydrophobic IOL to inhibit the adhesion of lens epithelial cells can prevent the occurrence of after-cataract and endophthalmitis. (Int Rev Ophthalmol, 2024, 48:  411-415)

Key words: intraocular lens, cataract, endophthalmitis