International Review of Ophthalmology ›› 2025, Vol. 49 ›› Issue (4): 269-275.doi: 10. 3760/cma.j.cn115500-20250316-25406

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Role of Caspase family proteins and oxidative stress damage in pathogenesis of cataracts and their clinical applications

Fan Meiqi1, Li Xiaoxia2, Jin Xiaohan1, Zhao Yizhuo3, Ma Lusheng2   

  1. 1 Qingdao University Qingdao Medical College, Qingdao Shandong 266000, China;2 Yantai Yuhuangding Hospital, Qingdao University, Yantai Shandong 264000, China;3 Second Clinical Medical College, Binzhou Medical University, Yantai Shandong 264000, China
  • Received:2025-03-16 Online:2025-08-22 Published:2025-08-12
  • Contact: Ma Lusheng, Email: 2708688668@qq.com E-mail:2708688668@qq.com

Abstract: The lens is a crucial structure for maintaining the transparency and refractive function of the eye. The regularly arranged lens fiber cells and uniformly distributed crystallins lay the foundation for excellent refractive imaging. Oxidative stress damage can disrupt the optical uniformity of the lens and is a significant contributor to the development of degenerative diseases such as age-relatedcataracts. Recent studies have found that Caspase family proteins are the core executors of apoptosis and are closely associated with the regulatory mechanisms of oxidative stress-induced damage in lens epithelial cells. The latest advancements in molecular biology and biochemistry have unveiled the intricate relationship among apoptosis pathways, oxidative damage, and lens transparency, highlighting key molecular mechanisms and potential therapeutic interventions.

Key words: Caspase family proteins, Oxidative stress, Lens, Apoptosis