Mechanism of endoplasmic reticulum stress and mitophagy in regulating the development of cataract

doi:10.3760/cma.i.cn115500-20251009-26110

International Review of Ophthalmology ›› 2026, Vol. 50 ›› Issue (1): 68-75.doi: 10.3760/cma.i.cn115500-20251009-26110

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Mechanism of endoplasmic reticulum stress and mitophagy in regulating the development of cataract

Yue Peilin, Wang Zhenyu, Song Xudong

Beijing Tongren Eye Center, Beijing Tongren Hospital,Capital Medical University; Beijing Key Laboratory of Ophthalmology & Visual Science, Beijing 100730, China

Received:2025-10-09 Online:2026-02-22 Published:2026-02-22
Contact: Song Xudong, Email: drxdsong@sina.com
Supported by:
National Natural Science Foundation of China (82271067)

Abstract

Abstract: The disruption of lens epithelial cell homeostasis is a critical event in cataract pathogenesis. Endoplasmic reticulum stress and mitophagy, as essential quality control mechanisms for maintaining lens homeostasis, become dysregulated under pathological conditions such as aging and oxidative stress. Their dysfunction creates a vicious cycle, jointly triggering lens epithelial cell apoptosis and lens opacification. Targeted regulation of key nodes in these processes may provide novel pharmaceutical strategies for the prevention and treatment of cataract.

Key words: Endoplasmic reticulum stress, Mitophagy, Cataract, Oxidative stress, Lens

Yue Peilin, Wang Zhenyu, Song Xudong.

Mechanism of endoplasmic reticulum stress and mitophagy in regulating the development of cataract [J]. International Review of Ophthalmology, 2026, 50(1): 68-75.

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Mechanism of endoplasmic reticulum stress and mitophagy in regulating the development of cataract

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