Abstract:  As a kind of multifunctional secreted glycoprotein, clusterin exists in different tissues of  human body and plays many physiological functions which show as its protective effects to retinal vascular endothelial cells and retinal pigment epithelial  (RPE) cells by reducing apoptosis. Besides, it can increase the synthesis of atresia zonule, and then promote the  proliferation  of corneal epithelial cell, and induce the differentiation of astrocytes and neurons. So a certain concentration of clusterin is necessary to maintaining normal stable structures of retina and conjunctival epithelial cells. In view of the important role of clusterin on the stable  maintaining of blood\|retinal barrier and ocular surface structure which is identified as the effective target of medicine for treating diabetic retinopathy (DR)  and age\|related macular degeneration (AMD), etc., and  also provide a new thought and method for the anterior segment diseases treatment, such as pseudoexfoliation glaucoma, Stevens syndrome, etc. (Int Rev Ophthalmol, 2013, 37: 403-406)