Abstract: Diabetic retinopathy (DR) is a kind of irreversible blindness caused by diabetes， and the number of patients is increasing year by year.Optical coherence tomography angiography (OCTA) with wider field of view and longer wavelength can display the location and shape of retinal microaneurysms in the three-dimensional space of DR eyes, distinguish retinal microvascular abnormalities and neovascularization,evaluate the activity of neovascularization, and the percentage of chorio capillaris flow deficit can predict the progress of DR. It is beneficial to the early screening and choroidal evaluation of DR patients and is expected to replace FA as a diagnostic tool for DR.OCTA quantitative analysis has the potential to detect DR early and monitor the progress of DR. Moreover，OCTA quantitative data output provides a unique opportunity for artificial intelligence，which is expected to establish a new and more convenient workflow for DR screening, diagnosis, treatment and follow-up. (Int Rev Ophthalmol, 2022, 46: 528-534)

Key words: optical coherence tomography angiography, diabetic retinopathy, artificial intelligence