The role of the vitreous microenvironment in the development of diabetic retinopathy

doi:10.3760/cma.j.issn.1673-5803.2023.02.010

International Review of Ophthalmology ›› 2023, Vol. 47 ›› Issue (2): 150-155.doi: 10.3760/cma.j.issn.1673-5803.2023.02.010

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The role of the vitreous microenvironment in the development of diabetic retinopathy

Huang Xiaofeng, Guo Tai, Zhao Hanpeng, Liu Yue, Cui Ying

Department of Ophthalmology, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China

Received:2022-09-22 Online:2023-04-22 Published:2023-04-22
Contact: Cui Ying, Email: cuiying@gdph.org.cn
Supported by:
National Natural Science Foundation of China (82000897); Science and Technology Program of Guangzhou(202201011700)

Abstract

Abstract: Diabetic retinopathy (DR) has a complex pathogenesis involving the accumulation of advanced glycosylation end products, oxidative stress, chronic inflammation, retinal ischemia and hypoxia, and neuronal degenerative disease, which leads to alterations in the vitreous microenvironment. The vitreous microenvironment refers to the surrounding structures and components in the vitreous cavity that can affect retinal cells and retinal neovascularization, which covers metabolites, physical components, cellular components, and biochemical components in the vitreous. The alteration of these components may promote the progression of DR through multiple pathways, such as protein kinase C activation, formation of advanced glycation end products, upregulation of cytokines, etc. Therefore, the study and understanding of the changes in the vitreous microenvironment are of great importance for preventing and treating DR.(Int Rev Ophthalmol, 2023, 47: 150-155)

Key words: diabetic retinopathy, vitreous, microenvironment

Huang Xiaofeng, Guo Tai, Zhao Hanpeng, Liu Yue, Cui Ying. The role of the vitreous microenvironment in the development of diabetic retinopathy[J]. International Review of Ophthalmology, 2023, 47(2): 150-155.

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The role of the vitreous microenvironment in the development of diabetic retinopathy

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