Tear osmolarity and dry eye disease

doi:10.3760/ cma.j.issn.1673-5803.2022.06.015

International Review of Ophthalmology ›› 2022, Vol. 46 ›› Issue (6): 559-565.doi: 10.3760/ cma.j.issn.1673-5803.2022.06.015

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Tear osmolarity and dry eye disease

Fang Zijie, Zhang Chen, Zhao Shaozhen

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, School of Optometry and Eye Institute, Tianjin Medical University Eye Hospital, Tianjin 300384, China

Online:2022-12-22 Published:2022-12-22
Contact: Zhao Shaozhen, Email:zhaosz1997@sina.com
Supported by:
Tianjin Clinical Key Discipline Project (TJLCZDXKM014)

Abstract

Abstract: Increased tear osmolarity is the prominent manifestation and core mechanism of dry eye disease. It can be measured by a variety of methods such as measurements upon electric impedance. Tear osmolarity fluctuates in a certain range which affected by self and environmental factors. The alteration of tear osmolarity is closely related to dry eye disease caused by multiple reasons. Increased tear osmolarity would cause inflammatory response, cell autophagy and oxidative stress. Tear osmolarity provides more ideas for exploring the pathogenesis and treatment effect of dry eye. (Int Rev Ophthalmol, 2022, 46: 559-565)

Key words: tear osmolarity, dry eye disease, ocular surface disease

Fang Zijie, Zhang Chen, Zhao Shaozhen. Tear osmolarity and dry eye disease[J]. International Review of Ophthalmology, 2022, 46(6): 559-565.

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Tear osmolarity and dry eye disease

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